TGFBITransforming Growth Factor, Beta-Induced
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Targeted disruption of TGFBI in mice reveals its role in regulating bone mass and bone size through periosteal bone formation.
5q31 lokusundaki keratoepitelin proteinini kodlayan TGFBI genindeki mutasyonlat granuler distrofi tip 1, lattis distrofisi tip 1, Avellino distrofisi ve Reis- Bucklers distrofisi gibi dominant kalitim gosteren kornea distrofilerine neden olabilir.
Several mRNAs, such as those encoding CYP1B1, IL8, neuronal pentraxin 1 (NP7X1), PAI2, PTGS2, NQ01, STAT1, TGFBI, THBSI, TNFRSF11B, and WNT5A, were induced in both types of cells by the AhR ligands TCDD and PCB-126, and the fold induction of expression was generally higher in precursors than in adipocytes [see Supplemental Material, Tables 1 and 2 (http://dx.