Jones and Robinson developed a triple immunostain for human breast cancer samples that simultaneously labels the three cell types that together they named TMEM (Tumor Microenvironment of Metastasis).
They found that TMEM density was more than double in the group of patients who developed systemic metastases compared with the patients with only localized breast cancer (median of 105 vs.
Notably, TMEM density was associated with the development of distant-organ metastasis, independent of lymph node status and tumor grade.
While these are useful measures, TMEM density directly reflects the blood-borne mechanism of metastasis, and therefore may prove to be more specific and directly relevant," said Dr.
The test, by scientists at the Albert Einstein College of Medicine at Yeshiva University, New York, discovered that for every 10-unit increase in TMEM density, the risk of metastatic cancer doubled.
The test detects the presence and density of TMEMs in breast tissue biopsy samples.
By measuring TMEM counts, we could identify those people and treat them appropriately.
A high number of TMEMs in a sample means that the tumour is likely to metastasise or already has.
Kazuhiko Miyadera has been appointed as executive vice president at TMEM
The MetaSite Breast test detects the TMEM
and is able to predict the likelihood of a woman with breast cancer to develop a distant metastasis, including spread to the liver, lungs, bone, brain and other organs.