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TP53 |
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However, the role of tumour suppressor gene mutations is indicated by their association with Li-Fraumeni syndrome, which is characterized by inactivating germline mutations of the TP53 gene, gives some insight into the origins of these tumours (1, 3). Most of the text is devoted to detailed information about specific candidate genes, but he also discusses inactivating events and the genes TP53 and BRCA one and two. The majority of gene carriers have either a BRCA1 or BRCA2 mutation, but a helpful table in this article summarises the role of TP53, ATM, PTEN and CHEK2. |
TP53 |
TP-ALL TP-DCS TP-IPT TP-JOR TP-PA TP-PMD TP-PMD TP-T Tp. Tp. Tp. Tp. TP/GFR TP/HB TP/IX TP/R TP/S TP/UMF TP/V TP0 TP0-TP4 TP1 TP2 TP2B TP3 TP30 TP4 TP5 TP53 TP9TPA TPA TPA TPA TPA-B TPA-Induced Sequence 7 TPA-IR TPA-R TPA/F TPAA TPAAA TPAB TPAC TPACC TPACP TPAD TPAE TPAF TPAG TPAGB TPAH TPAI TPAK TPAL TPAL TPAM TPAMI | |||||
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