TRAF6


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AcronymDefinition
TRAF6Tumor Necrosis Factor Receptor-Associated Factor 6 (protein)
References in periodicals archive ?
2014) NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.
Moreover, the expression of TRAF6 and NF-KB was significantly elevated in TG goats relative to RG goats (P<0.
As a key molecule in multiple pathways, TRAF6 expression was increased significantly in brain ischemia-reperfusion injury in the rat model [sup][23] and was also related to microglial activation.
In that article, the researchers show that TRAF6 is critical for the satellite cells to retain their stem properties and prevents them from undergoing premature differentiation.
Activation of the IkB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Our results showed that expression levels of TLR9, MYD88, IRAK1, TRAF6, and NF-[kappa]B in the PBMCs of CHB patients were 9.
Numerous homologs of TRAF6 can be found in cnidarian genes, including 11 in the coral and 8 in the anemone genome (Table 3) (Schnitzler, 2010).
TRAF6 bridges IRAK-1 and IRAK-2 to transforming-growth factor-[beta]-activated and NIK (20), NIK activates IKK complex.
For example, binding of LPS to TLR results in the activation of numerous intracellular adapters and kinases, such as MyD88, TRAF6, IKK, and MAP kinases (MAPKs), followed by DNA binding of transcription factors such as nuclear factor (NF) B and interferon (IFN) regulatory factor (IRF) 3 (see figure 3).