This analysis seems to demonstrate that the results of TRICC may be strongly influenced by the presence of non-comparable groups with different transfusion practices and are inadequate in each study group.
Given that the studies published before the TRICC indicated that clinicians used higher transfusion thresholds in patients with ischemic heart disease than in younger subjects with less comorbidity, none of the study groups represents the usual practice.
Data from the TRICC trial, in contrast, failed to support such a conclusion.
Looking at this question conversely, McIntyre et al (20) analyzed data from the TRICC trial, comparing outcomes in trauma patients who had been randomized to liberal and restrictive transfusion groups.
A recently published subset analysis of 357 patients with cardiovascular disease in the TRICC
trial addressed the issue raised by Hebert et a1 (38) regarding whether transfusion does, in fact, decrease mortality in anemic critical care patients with cardiac disease.