We identified the TRP domain, shared between mammalian TRPM and TRPC as well as Caenorhabditis elegans TRPN, Danio rerio TRPN, Drosophila TRPM, TRP[gamma], and TRPL, and Chlamydomonas reinhardtii TRP1 (Venkatachalam and Montell, 2007; Latorre et al.
Arachidonic acid and its breakdown products and/or compounds, including arachidonic acid, stimulate mammalian TRPC6, several isoforms of mammalian TRPV and TRPM, as well as Drosophila TRP and TRPL channels (Chyb et al.
Carvacrol, which inhibits mammalian TRPM and Drosophila TRPL (Parnas et al.
Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL.
Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels.
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