TSPG also showed the similar effects of lowering the hyperglycemia at 30 min by 24.
Though treatment with TSPG showed a trend to lower plasma levels of TG and TC, the differences remain not significant.
Treatment with both H-ROS and TSPG can improve the GGT in CS rats.
TSPG did not show a significant effect to increase the liver and muscle glycogen contents (p>0.
TSPG administration showed the similar effect by 22.
05), respectively; TSPG also showed the similar effect to plasma corticosterone level by 25.
05), L-ROS and TSPG showed the trends to increase the plasma leptin level but there is not significant difference compared with CS group.
TSPG was used as a positive control drug in this study, which has been demonstrated to have hypoglycemic effects and improvement of impaired HPA axis function induced by stress (Xie et al.
59% of body weight increase, and TSPG administration by 10.
The positive control drug, TSPG, also showed the similar regulatory effects on the glucose metabolism but with less effect on the liver and muscle glycogen.
Abbreviations: CS, chronic stress; DM, diabetes mellitus; FFA, free fatty acids; GGT, gluconeogenesis ability test; HPA, hypothalamic-pituitary-adrenal; IR, insulin resistance; N1M, neuroendocrine immuno-modulation; IPGTT, intraperitoneal glucose tolerance test; ROS, Rehmannia glutinosa oligosaccharide; T2DM, type 2 diabetes mellitus; TC, total cholesterol; TCM, traditional Chinese medicine; TG, triglyceride; TSPG, total saponins of Panax Ginsen.