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TTCW
(redirected from Time to Clinical Worsening)

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AcronymDefinition
TTCWTime to Clinical Worsening


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Secondary endpoints include time to clinical worsening, World Health Organization (WHO) Functional Class and Borg Dyspnea Index.
Secondary endpoints include time to clinical worsening of PAH during the 12-week placebo-controlled treatment period and change from baseline after 12 weeks in Borg dyspnea index (BDI, a measure of breathing ability), WHO functional class, SF-36[R] Health Survey physical functioning scale and various hemodynamic measures.
Time to clinical worsening was defined as the time from randomization to the first occurrence of death, lung transplantation, hospitalization for PAH, arterial septostomy, study withdrawal due to the addition of other PAH therapeutics or study withdrawal due to two or more predefined early escape criteria.
 
 
 
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