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20,21) However, the current availability of the topical immunomodulator imiquimod presents the option for an alternative approach to the management of extramammary Paget disease. Sirion's pipeline includes four late-stage opportunities: ganciclovir, a topical antiviral for herpetic keratitis which is awaiting an NDA filing; difluprednate, a potent topical steroid in Phase III development for post-operative inflammation and uveitis; cyclosporine, a topical immunomodulator in Phase III testing for dry eye and fenretinide, a first-in-class oral vitamin A binding protein antagonist in Phase II development for geographic atrophy associated with dry AMD. A class of drugs called topical immunomodulators, or TIMs, are the latest advancement for the treatment of eczema in more than 40 years. |
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