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To the Editor: Vibrio cholerae O1, the causative agent of cholera, has 2 biotypes (classical and El Tor), which have traditionally been distinguished by phenotypic tests and by genetic differences in the major toxin-coregulated pilus (TCP) gene, the tcpA allele of the TCP cluster (1), the rstR region (regulatory region for phage lysogeny) of CTX phages (2), the type of cholera toxin (CT) produced, and the infection pattern of the disease they cause. For example, the major toxin-coregulated pilus (TCP) gene, tcpA, of the TCP cluster possesses classical- and El Tor-specific alleles that encode identical functions but differ in their DNA sequence composition; however, the rtxC gene of the repeat in toxin (RTX) cluster is present in El Tor strains only and absent in classical strains (2,3). |
Toxin-Coregulated Pilus |
Toxics Use Reduction Institute Toxics Use Reduction Planner Toxics Use Reduction Program toxicyst Toxidrome Toxifera toxiferous toxiferous toxigenic toxigenic toxigenic toxigenic toxigenic diarrhea toxigenic diarrhea toxigenic diarrhea toxigenicity toxigenicity toxigenicity toxin toxin toxin toxin toxin toxin agent toxin antitoxin Toxin Research International toxin-antitoxin toxin-antitoxin toxin-antitoxin Toxin-antitoxin reaction Toxin-Coregulated Pilus Toxin-Induced Myasthenia Gravistoxinic toxinogenic Toxinology Toxins Toxins Toxins Toxins Toxins in Nerium oleander Toxins in Nerium oleander Toxins in Nerium oleander Toxins, biological Toxins, biological Toxins, biological Toxins, biological toxipathic toxipathic hepatitis toxipathic hepatitis toxipathic hepatitis toxipathy toxipathy Toxiphobia TOXLINE TOXLIT TOXNET Toxo Toxo Toxo toxo- toxo- | |||||
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