| Acronym | Definition |
|---|
| TLC | The Learning Channel |
| TLC | Tender Loving Care |
| TLC | Tratado de Libre Comercio (English: NAFTA) |
| TLC | Tratado de Libre Comercio |
| TLC | Teaching/Learning Center |
| TLC | Thin Layer Chromatography |
| TLC | Technology Learning Center |
| TLC | The Library Corporation |
| TLC | Toyota Land Cruiser |
| TLC | Telecomunicazioni |
| TLC | Total Lung Capacity |
| TLC | The Leaky Cauldron (Harry Potter website) |
| TLC | Transitional Learning Center |
| TLC | Taxi & Limousine Commission (New York City) |
| TLC | The Learning Company |
| TLC | Texas Legislative Council |
| TLC | Tastes Like Chicken |
| TLC | Teaching and Learning Centre (Australia) |
| TLC | Total Logistic Control |
| TLC | The Laser Center (laser vision correction) |
| TLC | Tender Love and Care (song) |
| TLC | Therapeutic Lifestyle Change |
| TLC | The Last Crusade (Indiana Jones movie) |
| TLC | Trilateral Commission |
| TLC | Trinity Lutheran College |
| TLC | Trichotillomania Learning Center (Santa Cruz, CA) |
| TLC | Total Luxury Care (Acura) |
| TLC | TACOM (Tank-Automotive and Armaments Command) Learning Center |
| TLC | The Legend Continues (Kung Fu TV show) |
| TLC | Total Lymphocyte Count |
| TLC | Transportation for Livable Communities |
| TLC | Teaching and Learning Committee |
| TLC | Transformative Learning Centre (Ontario Institute for Studies in Education, University of Toronto) |
| TLC | The Latino Coalition (Washington, DC) |
| TLC | The Lego Company |
| TLC | Total Leucocyte Count |
| TLC | Triple-Lumen Catheter |
| TLC | Tables & Ladders & Chairs (pro wrestling) |
| TLC | The Living Church |
| TLC | Tasty Little Crackers (Kashi Company) |
| TLC | Touro Law Center |
| TLC | Transitional Local Council |
| TLC | Thermochromic Liquid Crystal |
| TLC | The Leadership Center |
| TLC | Three Letter Code |
| TLC | Teen Leadership Conference |
| TLC | Technology Life Cycle |
| TLC | Truth in Labeling Campaign |
| TLC | Tiwi Land Council (statutory authority representing Aboriginal Owners of Tiwi Islands) |
| TLC | Technology Life Careers |
| TLC | Targeted Learning Corporation |
| TLC | The Lobster Conservancy (Friendship, ME) |
| TLC | Texas Land & Cattle (restaurant) |
| TLC | Through-Life Cost (financial management) |
| TLC | Texas Lutheran College |
| TLC | Trivial Loot Code (Everquest game) |
| TLC | Tech Logic Corporation (library services company) |
| TLC | Tasty Little Chewies (Kashi Company) |
| TLC | Tripp Lake Camp (Poland, Maine) |
| TLC | Timber Lake Camp (Shandaken, NY) |
| TLC | TrueLicense Library Collection |
| TLC | Team Leadership Center |
| TLC | Transformation Life Cycle |
| TLC | Transformational Learning Connections |
| TLC | Translunar Coast |
| TLC | Tough Logging Conditions (oil industry) |
| TLC | Tender Loving Cuisine (Five Dock, NSW, Australia) |
| TLC | Transports du Loir-et-Cher (French transportation company) |
| TLC | Tennessee Llama Community |
| TLC | T-Boz, Left Eye, & Chili (the band TLC) |
| TLC | TransLogistique, Canada (Logistics and SCM training) |
| TLC | The Loveline Companion |
| TLC | Term Loan C |
| TLC | Trafikledningscentral |
| TLC | Transgender Liberation and Care |
| TLC | Trades and Labor Council of Western Australia |
| TLC | Tourisme Loisirs Culture (French: Tourism Leisure Culture) |
| TLC | Toxic Links Coalition |
| TLC | Textile-Linge-Chaussures (French: Textile-Linen-Shoes; industry) |
| TLC | The Learning Collaborative (Columbia, South Carolina) |
| TLC | Toys for Local Children (charity) |
| TLC | Top Line Creations, LC (SLC, Utah) |
| TLC | The Lost Creatures (gaming clan) |
| TLC | Trout Lake Camps (Pine River, MN) |
| TLC | Test Loop Combination |
| TLC | Traffic Load Control |
| TLC | Trac Lapping Club |
| TLC | Territory Logistics Center (FEMA) |
| TLC | The Last Conformist (movie) |
| TLC | Transportation & Logistics Council, Inc. (formerly Transportation Consumer Protection Council, TCPC) |
| TLC | Teacher Leadership Council (Mormon Church) |
| TLC | Total Lack of Consideration |
| TLC | Transmission Line Coupler |
| TLC | Total Loss of Capacity (SDH or Sonet Technology) |
| TLC | Tomatoes, Lettuce, and Cheese |
| TLC | The Laughing Classroom (book) |
| TLC | Totally Lost and Confused |
| TLC | Tailored Logistics Corporation (defense contractor specializing in the development of component overhaul kits) |
| TLC | Temporary Labor Camp |
| TLC | Tactical Leaders Course |
| TLC | Total Lateral Clearance (highway capacity, civil engineering) |
| TLC | Trotskyist League of Canada |
| TLC | Transport-, Informatik-, Logistik-Consulting GmbH |
| TLC | Texas Logistics Corporation |
| TLC | Teen Life Conference |
| TLC | Tactical Landing Craft |
| TLC | Telecommunication Line Controller |
| TLC | The Lord's Chapel (Winchester, VA) |
| TLC | Two Letter Clan (gaming clan) |
| TLC | Team Life Care Insurance Pvt Ltd (India) |
| TLC | Transport Logical Connection (Ciena) |
| TLC | Tuckerton Lumber Company |
| TLC | Total Lines of Code |
| TLC | Trunk Logic Circuit (Nortel) |
| TLC | Tunable Laser Channel (Agilent) |
| TLC | Tri-Level Compression (ACS Communications) |
| TLC | Telephone Line Control |
| TLC | Ternary Linear Code |
| TLC | Toastmasters Learning Center |
| TLC | Transformer-rectifier Line Contactor |
| TLC | Traffic Light Chart (integrated three-tiered reporting system/format) |
| TLC | Thunderbird Language Center (AGSIM, Glendale, AZ, USA) |
| TLC | Transitional Line Charge |
| TLC | Tough Luck Chump (Internet slang) |
| TLC | Tough Luck Charlie |
| TLC | Tokyu Land Corporation (Japan) |
| TLC | The Leadership Challenge (est. 1983) |
| TLC | The Loose Cannons |
| TLC | Turbine Load Control (wind turbines) |
| TLC | The Literacy Community (various organizations) |
| TLC | The Luggage Club (est. 2005) |
| TLC | The Local Connection (various locations) |
| TLC | The Landsburg Company (est. 1984) |
| TLC | The Life Cycle Cost Company Ltd (UK) |
| TLC | Transamerica Life Canada (est. 1927) |
| TLC | The Love Calculator |
| TLC | Top Left Corner |