| Acronym | Definition |
|---|
| TPE | Thermoplastic Elastomer |
| TPE | Travaux Personnels Encadrés (French: Supervised Personal Work; academics) |
| TPE | Twisted Pair Ethernet |
| TPE | Terminal de Paiement Electronique (French) |
| TPE | Therapeutic Plasma Exchange |
| TPE | Total Power Exchange |
| TPE | Turboprop Engine |
| TPE | Telomere Position Effect |
| TPE | Tampines Expressway (Singapore) |
| TPE | Theater Provided Equipment |
| TPE | That Petrol Emotion (band) |
| TPE | Très Petites Entreprise (French: Very Small Business) |
| TPE | Test Project Engineer (US NASA) |
| TPE | Third Pole Environment |
| TPE | Telework Partnership with Employers |
| TPE | Taxpayer Education |
| TPE | Teacher Performance Evaluation |
| TPE | Third Party Evaluator |
| TPE | Technology, Pedagogy and Education |
| TPE | Third Party Equipment (various organizations) |
| TPE | Threshold Photoelectron |
| TPE | Trade Promotion Excellence (Kellogg) |
| TPE | Taipei, Taiwan - Taiwan Taoyuan International Airport (airport code) |
| TPE | Tiny Paper Enclosure (philately) |
| TPE | Tris Phosphoric Ethylenediaminetetraacetic Acid |
| TPE | Transaction Processing Executive |
| TPE | Trainer-Peculiar Equipment |
| TPE | Trans-Pacific Exchange (now VIA; Stanford, CA) |
| TPE | Tracking and Pointing Experiment |
| TPE | Tracking & Pointing Experiment |
| TPE | Training Project Engineer |
| TPE | Teens for Planet Earth (Wildlife Conservation Society; Bronx Zoo; New York) |
| TPE | The Power Empire (gaming clan) |
| TPE | Transaction Processing Environment (UniKix) |
| TPE | The Public Enemy |
| TPE | Therapeutic Patient Education |
| TPE | The Public Employee (Singapore; newsletter) |