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A series of promoter constructs was generated in which either a single or both transcription factor binding sites were altered by point mutations in the -55/+154 construct (Fig. 1 million probe arrays are a flexible and robust platform for investigating the transcription factor binding sites and chromatin modification patterns in the genome of a variety of model organisms and have been extremely valuable for our research of the transcriptional regulatory elements in the From these studies, one can conclude that the regulation of MMP-13 gene expression is complex and dependent on the co-operation of neighboring and distal transcription factor binding sites ancillary to the AP-1 site. |
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