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Specifically, the two partners elucidated that carnosic acid, which is found in rosemary, substantially stimulates the activity of Nrf2, a kind of transcription factor, promoting the growth of neuritis. Consistent with this model, feed-forward loops (in which a transcriptional regulator controls a second transcription factor that then functions in concert with the initial regulator on a common downstream target gene) are emerging as common mechanisms in eukaryotes for transcriptional networks (Lee et al. We didn't expect that just one transcription factor could turn on atrophy," says Goldberg. |
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