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The authors exposed mouse mesenchymal cells to lead in vitro and observed signaling changes in several proteins active in chondrogenesis: transforming growth factor-beta (TGF-[beta]), bone morphogenetic protein (BMP), activating protein 1 (AP-1), and nuclear factor kappa B (NF[kappa]B). First, by attaching to a molecule called transforming growth factor-beta, the receptor sends a strong growth-inhibiting signal to its cell. Transforming growth factor-beta 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells. |
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