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References in periodicals archive ?
Persistently high homocysteine levels warrant treatment with higher vitamin doses or trimethylglycine, he said.
Adequate B complex, including folates, paraaminobenzoic acid (PABA), biotin, betaine, or trimethylglycine (TMG) is important as methyl donors or for methyl group transfers.
Alternative health therapies (eliminating toxic metals from endothelium with long term oral chelation, treating endothelial infections with tumeric, high doses of vitamin C and lysine{Linus Pauling}, N-acetyl cysteine, L-arginine, lowering homocysteine values with pyridoxine, folic acid, B12 and trimethylglycine, curtailing sugar intake, Vitamin K2 [removes calcium from arterial plaque and places calcium in bone] and use of Mediterranean diet) would promptly heal patients with arteriosclerosis.
Furthermore, methylation disorders can often be corrected with the orthomolecular administration of folinic acid, trimethylglycine, pyridoxine, and methycobalamin.
Drug options: Elevated homocysteine blood levels can usually be brought into safer ranges by taking folic acid, vitamin B12, trimethylglycine (TMG), and vitamin B6 dietary supplements.
General Vitamin Neurological Health Formula (a multivitamin, multimineral supplement including antioxidants, trimethylglycine, nucleotides, supplements to support the sulfur metabolism, a high ratio of magnesium to calcium, and no iron or copper)1 (13): starting with V4 tablet and increasing the dosage as tolerated, to 2 tablets daily
Nonetheless, to prevent the possibility of elevated homocysteine, the Physician's Desk Reference[R] recommends taking supplemental vitamins B6, B12, and folic acid, and possibly trimethylglycine (TMG), while using supplemental SAMe.
This is a particular genetic "SNIP" (actually SNP, for single nucleotide polymorphism) that causes abnormal amounts of homocysteine to be made from cysteine in about 28% of patients and can be treated by adequate supplementation of folic acid, lysine, B6, and trimethylglycine.
High doses of trimethylglycine appear to be a very effective therapy for lowering homocysteine values; up to 9 grams daily may be needed to bring them into a safe range (below 10 micromoles per liter).
The homocysteine theory is based on the fact that a dietary imbalance between too much methionine (an essential amino acid) and a deficiency of methylating nutrients (B6, B12, folic acid, and methyl donors, such as trimethylglycine [TMG] and trimethylaminoethanol [choline]), is an underlying cause of death and disability from vascular diseases.