| Acronym | Definition |
|---|
| TLE | Temporal Lobe Epilepsy |
| TLE | The Leading Edge |
| TLE | Taxe Locale d'Équipement (French: special local construction tax) |
| TLE | Two Line Elements (for satellite tracking) |
| TLE | The Living End (band) |
| TLE | Temporary Lodging Expense |
| TLE | The Learning Equation |
| TLE | Target Location Error |
| TLE | Tire Lube Express (Wal-Mart) |
| TLE | Treaty Limited Equipment |
| TLE | Time Limit Exceeded |
| TLE | Technique de Libération Emotionnelle (French: Emotional Freedom Techniques; behavioral health) |
| TLE | Théorie, Littérature, Enseignement (French: Theory, Literature, Education; journal review) |
| TLE | Technology and Livelihood Education |
| TLE | Thin-Layer Electrophoresis |
| TLE | The Learning Exchange (Vimont, Laval, QC, Canada) |
| TLE | Team Laser Explosion (Weebl & Bob forum) |
| TLE | The Long Emergency (book by Jim Kunstler) |
| TLE | Technology & Livelihood Education |
| TLE | Transfer Line Exchanger |
| TLE | Trusted Link Enterprise |
| TLE | Tag Logical Element (IBM AFP Structured Field) |
| TLE | The Living Enterprise (book) |
| TLE | Thai Language Edition (Thailand) |
| TLE | Threaded Large End |
| TLE | Temperature-Limited Emission |
| TLE | Temporal Logic Expression |
| TLE | Type Load Editor (transportation) |
| TLE | Track Localization Error |
| TLE | Traffic Logging Equipment |
| TLE | Tactical Legion of Enforcers (gaming clan) |
| TLE | Turbo Linear Equalization |
| TLE | Transponder-Lightpath Edge |
| TLE | Thomas Lake Elementary (Eagan, MN) |
| TLE | Temporary Learning Elsewhere |
| TLE | Transmission-Line Effect |
| TLE | Travel Lines Express |
| TLE | The Libertarian Enterprise (L. Neil Smith publication) |
| TLE | The Lost Experience (game) |
| TLE | Transient Luminous Events |
| TLE | Traffic Law Enforcement (police) |
| TLE | Team Loyalty Entertainment (Milwaukee, WI) |