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Animals treated with a combination of lucanthone and pemetrexed showed an approximately 45% tumor growth inhibition demonstrating that lucanthone is synergistic with pemetrexed. Administration of the combination over a 28 day period induced tumor growth inhibition (TGI) of 93% for 49 days (p<0. This anti-angiogenic effect has been shown to starve tumors of their nutrient supply and results in significant tumor growth inhibition in pre-clinical models. |
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