| Acronym | Definition |
|---|
| TWC | The Weather Channel |
| TWC | Time-Warner Cable |
| TWC | Texas Workforce Commission (also seen as TWFC) |
| TWC | The Washington Center |
| TWC | The Wellness Community |
| TWC | Trustworthy Computing |
| TWC | Teachers & Writers Collaborative |
| TWC | The Wig Company (Pittsburgh, PA) |
| TWC | Tennessee Wesleyan College (Athens, Tennessee) |
| TWC | Three-Way Catalyst (automotive) |
| TWC | Texas Water Commission |
| TWC | Time Warner Center (New York City) |
| TWC | Two Way Communication |
| TWC | Third World Country |
| TWC | Time-Warner Communications |
| TWC | Track Warrant Control (railroad systems) |
| TWC | Three-Way Calling |
| TWC | Tylenol With Codeine |
| TWC | Total Water Content |
| TWC | The Wrestling Channel |
| TWC | Technical Working Committee |
| TWC | The Wisden Cricketer (magazine; UK) |
| TWC | Top Web Comics |
| TWC | The Windows Club (online forum) |
| TWC | Tsunami Warning Centre |
| TWC | The Wilderness Center (Wilmot, OH) |
| TWC | Trade Working Capital |
| TWC | The Wesleyan Church |
| TWC | Tunable Wavelength Converter |
| TWC | Texas Wesleyan College (now University) |
| TWC | The Wellness Coalition (New Mexico) |
| TWC | Office for Counterterrorism Analysis (DIA) |
| TWC | Tank, Water, City |
| TWC | Treatment, Workover and Completion |
| TWC | Tank, Water, Chilled |
| TWC | Traveling Wave Chopper |
| TWC | Tank, Water, Cool |
| TWC | The Wakefield Corporation |
| TWC | Teen's with Crohn's |
| TWC | Techwebcast |
| TWC | Toxic Waste Center |
| TWC | Theater Warfare Center |
| TWC | Tomahawk Workstation Center (ATWCS) |
| TWC | Target Wadcutter (bullet) |
| TWC | Technical Writing Consultant |
| TWC | Theater Weather Center |
| TWC | Thick Wall Cylinder |
| TWC | Tuningwerks Competition (automotive) |
| TWC | The Werewolf Council (gaming) |
| TWC | Total Working Cost (financial management) |
| TWC | Thomas Winter Cooke, Inc. |
| TWC | The Water Closet (Texas) |
| TWC | Technical Writing and Communication (various schools) |
| TWC | Total Water Current (US DoD) |
| TWC | The War Council (gaming) |
| TWC | Telford & Wrekin Council (UK) |
| TWC | The Writing Centre (various locations) |
| TWC | The Weinstein Company (film studio) |
| TWC | Two Way Channel |