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TK+
(redirected from Tyrosine Kinase Domain)

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AcronymDefinition
TK+Tyrosine Kinase Domain
TK+thymidine kinase positive
TK+thymidine kinase competent


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These drugs inhibit the EGFR pathway by binding to the intracellular tyrosine kinase domain.
All family members have an intracellular tyrosine kinase domain, except for HER-3.
Cytogenetic studies have demonstrated translocations between chromosomes 12p13 and 15q25 that lead to the gene fusion product ETV6-NTRK3 with an intra-cellular tyrosine kinase domain.
 
 
 
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