11] Nonstandard abbreviations: Cl, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; GDF-15, growth differentiation factor-15; hsTnI, high-sensitivity troponin I; IDI, Integrated discrimination improvement; NRl, net reclassification Improvement; OR, odds ratio; sST2, soluble ST2; UACR
, urinary albumin to creatinine ratio.
73 m2, UACR >300 and <5,000 mg/g, and systolic blood pressure within 110 and 160 mgHg.
75 mg/day for six weeks to determine their UACR response and to assess tolerability of atrasentan.
9 percent) patients met UACR
(30 to 3,000 mg/g creatinine) and estimated glomerular filtration rate (eGFR; >30 mL/min/1.
In a post hoc analysis, it was shown that the greatest reduction in UACR was in 29 patients on 2 mcg paricalcitol who had urinary sodium excretion of more than 178 mmol in 24 h.
We have shown that 24 weeks' treatment with 2 mcg paricalcitol daily reduced residual albuminuria in patients with type 2 diabetic nephropathy who were on stable doses of ACE inhibitors or ARBs, particularly in those with high dietary sodium intake," the investigators wrote, adding that the effect on albuminuria, systolic blood pressure, and eGFR all occurred within 4 weeks, and that the reductions in UACR and eGFR were "fairly stable during the treatment phase.
In an unadjusted analysis, both hs cardiac troponin assays and UACR, but not [eGFR.
Each cardiac troponin was significantly associated with UACR (hs cTnI, [beta] = 0.
The independent association of both hs cardiac troponin assays with eGFR and UACR in this study identifies potential renal-specific mechanisms of cardiac injury that are not identified by cardiac imaging.
The fact that both cardiac troponin assays remain independently correlated with eGFR calculated by both cystatin C- and creatinine-based formulas as well as another measure of renal function, UACR, supports the finding that the extent of measured cardiac injury by hs cardiac troponin assays is associated with the extent of renal impairment.
The study's primary endpoint was mean change in UACR
ratio from baseline to each treatment visit.
This included patients from four clinical trials (n=2,472) who had early diabetic nephropathy and were on stable ACE/ARB therapy and elderly patients from all seven trials (n=377) who had diabetic nephropathy and met the UACR
inclusion criteria (30 to 3,000 mg/g creatinine).