Compared to those without CKD, patients in CKD Stages 1–2 and CKD Stages 3–5 had higher risks of CHD, fatal CHD, stroke, and fatal stroke, as calculated by the UKPDS
risk engine [ P < 0.
Jellinger, "a significant cardiovascular benefit was also shown in the tightly controlled patients with type 2 diabetes in the UKPDS
study in the 10-year follow-up analysis.
In the UKPDS
, patients who were on metformin and a sulfonylurea demonstrated a doubling in the cardiovascular event rate," Dr.
Most were derived using prevalent T2DM cases, and only the UKPDS
tool was derived using newly diagnosed diabetic patients.
A strong linear correlation between the levels of HbA1c and glycemia in the diabetic patients was found using the results from a big retrospective study, primarily the DCCT and the UKPDS
[5-7], as well as from the studies of other authors [11-13], and it was the cause to perform the A1C-Derived Average Glucose (ADAG) study.
Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS
1c] assays in calibrating their methods so that patient values correlate with those of the DCCT and the UKPDS
4-6) Em um grupo de participantes do UKPDS
(11) selecionado para permanecer em seguimento por 10 anos apos a conclusao do estudo, o controle mais intenso e precoce da glicemia (HbA1c: 7,0% vs.
Outcomes Model requests the duration of diabetes as well as risk factor values at diagnosis of diabetes.
The Diabetes Control and Complication trial (DCCT)  and UK Prospective Diabetes Study UKPDS
 have shown that major diabetic complications can be markedly reduced by maintaining near normoglycaemia.
ten-year follow-up (116) also demonstrated delayed beneficial effects of early initiation of glycaemic control on macrovascular outcomes, a "metabolic memory" of sorts.
Intensive insulin therapy has been shown to decrease the risk of microvascular complications in T1DM and T2DM; however, it is also associated with an increased risk of hypoglycemia (DCCT Research Group, 1993; UKPDS