In the UKPDS
, patients who were on metformin and a sulfonylurea demonstrated a doubling in the cardiovascular event rate," Dr.
1c] assays in calibrating their methods so that patient values correlate with those of the DCCT and the UKPDS
Outcomes Model requests the duration of diabetes as well as risk factor values at diagnosis of diabetes.
Group, Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS
To summarise, the main UKPDS
(11) findings are that improved control of plasma glucose and blood pressure reduce the risk of:
1c]; DCCT, Diabetes Control and Complications Trial; UKPDS
, United Kingdom Prospective Diabetes Study; NGSP, National Glycohemoglobin Standardization Progam; SI, Systeme International d'Unites; IQR, interquartile range.
When last published, this conclusion was criticized because the study failed to account for imperfect compliance with guideline recommendations; because Vijan, Hofer, and Hayward (2000) used what some argued was an arbitrarily high utility value for vision loss; and because it used UKPDS
retinopathy progression data, which some thought underestimated retinopathy progression rates experienced in U.
Analyses of the DCCT and UKPDS
trial outcomes linked HbA1c measurements to average blood-glucose control vs.
has shown that treatment of Type 2 diabetes does not reduce cardiovascular end-points significantly, but that aggressive treatment of blood pressure can do so.
Holman, a primary UKPDS
investigator and director of the University of Oxford Diabetes Trials Unit.
8 percent across strategies, and the UKPDS
reduced it by 0.
If this hypothetical standard were not linked or traceable to the UKPDS
or DCCT results, then it, too, could be misleading for generalists and patients.