UPEPUrine Protein Electro-Phoresis
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As a screening assay, MASS-FIX identified an M-protein in every case that was positive by SPEP or UPEP.
The first autgregressive coefficient is negative and, except for UPEP and current capacity in column (3), significant.
In the first regime, the autoregressive coefficient is negative and, again except for UPEP and current capacity in column (7), significant.
The FLC results in Table 3 indicate that the guidelines for serum FLC need to be more stringent and more closely resemble the UPEP guidelines rather than the SPEP guidelines.
4] Nonstandard abbreviations: SPEP, serum protein electrophoresis; UPEP, urine protein electrophoresis; MM, multiple myeloma; MGUS, monoclonal gammopathy of undetermined significance; SMM, smoldering MM; IMWG, International Myeloma Working Group; FLC, free light chain; iFLC, involved (monoclonal) FLC; rFLC, ratio of [kappa] to [lambda] FLC; uFLC, uninvolved FLC.
Early posttransplantation serum protein electrophoresis and serum immunofixation electrophoresis studies (at approximately 2 months) and UPEP studies (at 6 weeks) showed a small (3.
As a gauge of patients' response to therapy, serial UPEP studies combined with densitometric scanning are commonly used to measure changes in Bence Jones protein excretion over time.
In accordance with other reports, a monoclonal peak with a [beta] mobility was present after both SPEP and UPEP.
To investigate which protein was mainly responsible for the monoclonal peak observed after UPEP (4), we performed co-immunofixation of both serum and urine proteins (Fig.
This patient serves as a reminder that FLC assays cannot replace SPEP as a screening test but can identify additional patients with light disease that may be missed by a combination of SPEP and UPEP.
The annual costs incurred by replacing UPEP and urine IFE with serum FLCs were based on the following assumptions: (a) a urine sample was received with every request for SPEP; (b) postanalytical costs were equivalent for urinalysis and serum FLC analysis; (c) no additional preanalytical costs were incurred by introducing serum FLCs on samples received for SPEP; (d) staff costs for the automated analysis of urine total protein were considered insignificant and not included; (e) no significant additional staff costs were incurred for serum FLC analysis, which was performed on the same analyzer as serum total protein and albumin; (fl estimates were based on costs and workload data (2800 samples for SPEP and serum FLC analysis) for the period spanning Apri12004 to March 2005.
Preanalytical costs for UPEP and urine IFE were then estimated as a proportion of all sample reception staff costs.