11,22) Furthermore, as described above, endometrial stromal tumors, including low-grade endometrial stromal sarcoma, endometrial stromal nodule, and ESTSCLE, show t(7; 17)(p15; q21) translocation; however, no specific or significant genetic alteration, including t(7; 17), is observed in UTROSCT.
The neoplastic cells are invariably positive for smooth muscle actin, caldesmon, and CD99 in a more diffuse fashion, which may be observed in UTROSCT but to a lesser extent.
However, calretinin, inhibin, cytokeratin 7, and epithelial membrane antigen are negative, in contrast to UTROSCT.
A UTROSCT is generally discovered only after hysterectomy, and most of the patients reported so far were managed with hysterectomy with or without bilateral salpingo-oophorectomy.
Also, because UTROSCT has no specific imaging findings, preoperative differential diagnosis from other tumors can be difficult.
Macroscopic image of uterine tumor resembling ovarian sex cord tumor (UTROSCT): Tan-yellow to tan -white, cut surfaces of an UTROSCT (upper left, lower left, and lower right), in contrast to the whorled tan-white cut surface of an intramural leiomyoma (upper right) present in the same hysterectomy specimen.
The UTROSCTs generally present as intramural, submucosal, and subserosal masses, usually in the uterine fundus.