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UPR |
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Our gene expression analysis also suggests another novel aspect underlying methapyrilene-mediated hepatotoxicity, namely, ER stress resulting from the unfolded protein response [reviewed by Boyce and Yuan (2006)]. S-glutathionylates Serum Proteins in Mice, and Induces the Unfolded Protein Response Via Oxidative Signaling In Tumor Cells The accumulation of unfolded proteins in the lumen of the ER causes ER stress and induces a coordinated adaptive program called the unfolded protein response (UPR). |
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