| Acronym | Definition |
|---|
| UPA | Usability Professionals' Association |
| UPA | United Progressive Alliance (Indian political group) |
| UPA | University Publications of America |
| UPA | Ultimate Players Association |
| UPA | Union des Producteurs Agricoles (Canada; Union) |
| UPA | University of Pennsylvania |
| UPA | Universal Powerline Association |
| UPA | Unión de Pequeños Agricultores (Spanish: United Small Farmers) |
| UPA | United Productions of America |
| UPA | Ultra Port Architecture (High Bandwidth for Display) |
| UPA | Uniform Partnership Act (Law) |
| UPA | Un Paso Adelante (Spanish TV drama) |
| UPA | USA Patriot Act |
| UPA | United Palestinian Appeal (Washington, DC) |
| UPA | Urban Priority Area |
| UPA | Utah Psychological Association |
| UPA | United Protestant Association |
| UPA | United Pilots' Alliance (gaming) |
| uPA | Urokinase-Like Plasminogen Activator (a protease) |
| UPA | Utopia Pathway Association |
| UPA | Units Per Assembly |
| UPA | Universal Port Aventura (Spanish Universal theme park) |
| UPA | Unit Pentadbiran Am (Malaysian government agency) |
| UPA | Undergraduate Policy Analysis (UC, Berkeley) |
| UPA | Ukrainian Planetariums Association |
| UPA | Unauthorized Precedence Announcement |
| UPA | Union Postale Arabe (Arab Postal Union) |
| UPA | Unit Pay Administrator |
| UPA | United Professionals' Association |
| UPA | Up Auxiliary |
| UPA | Units Per Application (US Navy supply) |
| UPA | Ukrainskaya Povstancheskaya Armiya (pro-Nazi WWII organization in Ukraine; Ukraine Rebel Army) |