| Acronym | Definition |
|---|
| UCS | Unified Computing System (Cisco) |
| UCS | Universal Character Set |
| UCS | Union of Concerned Scientists |
| UCS | Universal Multiple-Octet Coded Character Set |
| UCS | Universidade de Caxias do Sul (Brazil) |
| UCS | University Campus Suffolk (Ipswich, UK) |
| UCS | User Coordinate System |
| UCS | Unconfined Compressive Strength |
| UCS | Unconditioned Stimulus |
| UCS | Utica Community Schools (Michigan) |
| UCS | University College School (London, England) |
| UCS | Unified Communications System |
| UCS | United Civilized States |
| UCS | Uniaxial Compressive Strength |
| UCS | Uniform Communication Standard |
| UCS | Uniform Chromaticity Scale |
| UCS | Unified Command Suite |
| UCS | Unión Cívica Solidaridad (Bolivia, Civic Solidarity Union) |
| UCS | Unified Communications Service |
| UCS | University Computer Services |
| UCS | Universal Classification System |
| UCS | Universal Computer Services (Johannesburg, South Africa) |
| UCS | Unicode Conversion Support |
| UCS | Universal Component System |
| UCS | Universal Chassis System |
| UCS | Ultimate Collector's Series (Lego) |
| UCS | Universal Coordinate System |
| UCS | United Cyber Squad (gaming) |
| UCS | United Christmas Service |
| UCS | Universal Card Service (AT&T) |
| UCS | Universal Cabling System |
| UCS | Universal Card Slot |
| UCS | United Container Systems |
| UCS | Universal Camera Site |
| UCS | Universal Communication Standards |
| UCS | Underwater Combat System |
| UCS | Unitrade Specialized Canada Catalog (philatelic catalog) |
| UCS | Uncommanded Slats Deployment (aviation) |
| UCS | Universal Carrier Services |
| UCS | Universal Carrier Services (Nortel) |
| UCS | Upon Close Scrutiny |
| UCS | Universal Communications Systems, Incorporated |
| UCS | Up Center Stage |
| UCS | Universal Connectivity System (network connectivity and monitoring) |
| UCS | University Counselling Service (various locations) |
| UCS | UConn (University of Connecticut) Conference Services (Storrs, CT) |
| UCS | Upper Cervical Spine |
| UCS | University Computer System |
| UCS | University of Connecticut, Storrs (Storrs, CT) |