7 times the upper limit of normal
, investigators calculated a positive predictive value of 95% and 98%, respectively.
5) Myopathy is present in such patients if creatine kinase is more than 10 times the upper limit of normal
Seven (78%) of the later Tanner stage boys had hematocrit levels above the upper limit of normal
Use lower initial dosage and caution in titration Bupropion Severe cirrhosis: do not exceed 75 mg/d IR, 100 mg/d or 150 mg SR every other day, 150 mg XL every other day Reduce dosage or less frequent dosing in mild-to-moderate impairment Citalopram Do not exceed 20 mg/d Desvenlafaxine Do not exceed 100 mg/d Duloxetine Do not use with any degree of hepatic impairment Escitalopram Do not exceed 10 mg/d Fluoxetine Reduce dosage or use less frequent dosing in impairment Nefazodone Discontinue in hepatocellular injury or liver function tests >3 x the upper limit of normal
Nortriptyline Initiate with caution in hepatic impairment Paroxetine Initiate: 10 mg/d (12.
Specificity/sensitivity of lipase and amylase for AP at cut-off level Acute pancreatitis, n Extrapancreatic conditions, n Serum lipase >3 x ULN 140 25 <3 x ULN 14 297 Serum lipase specificity for AP above threshold = 92% Serum lipase sensitivity for AP above threshold = 91% Serum amylase >3 x ULN 96 24 <3 x ULN 58 298 Serum amylase specificity for AP above threshold = 93% Serum amylase sensitivity for AP above threshold = 62% AP = acute pancreatitis; ULN = upper limit of normal
Abbreviations: ALT = alanine aminotransferase, DOD = Department of Defense, PRC = Polytrauma Rehabilitation Center, TBI = traumatic brain injury, ULN = upper limit of normal
, VA = Department of Veterans Affairs, VAMC = VA Medical Center.
Subsequently, a case was defined as acute hepatitis of unknown etiology occurring on or after April 1, 2013 in a person who had consumed a weight loss or muscle-building dietary supplement within the previous 60 days and had a serum alanine aminotransferase level greater than or equal to four times the upper limit of normal
(>160 IU/L) and a total bilirubin level greater than or equal to two times the upper limit of normal
Ten of the 29 patients in the study had at least one elevation in liver enzymes greater than or equal to three times the upper limit of normal
, including four patients who experienced liver enzymes greater than or equal to five times the upper limit of normal
5-fold above the upper limit of normal
for at least four months prior to start of the study.
ALT elevations at least 3 times the upper limit of normal
were observed in 14% of patients on mipomersen, versus none receiving placebo, but this occurred without concomitant significant bilirubin elevations, he said.
If HBeAg is positive, and/or ALT is more than twice the upper limit of normal
, the patient should be referred for tenofovir plus lamivudine or emtricitabine-based antiretroviral therapy (ART), as above.
7%) patients liver enzymes elevated more than three times the upper limit of normal
and only 11 patients (<0.