| Acronym | Definition |
|---|
| USC | United States Code |
| USC | University of Southern California |
| USC | University of South Carolina |
| USC | University of the Sunshine Coast (Queensland, Australia) |
| USC | Universidade de Santiago de Compostela (Spain) |
| USC | United States Constitution |
| USC | United States Citizen |
| USC | University of Santiago de Compostela (Spain) |
| USC | Universidad Santiago de Cali (Spanish) |
| USC | Upper St. Clair (Township, Pennsylvania) |
| USC | University of San Carlos (Cebu City, Philippines) |
| USC | Ultra Super Critical (Technologies) |
| USC | Under Separate Cover |
| USC | University of Southern Colorado (now Colorado State University-Pueblo; Pueblo, Colorado USA) |
| USC | United Somali Congress (political party) |
| USC | Urzad Stanu Cywilnego |
| USC | Unified Soil Classification |
| USC | universal service contract (US DoD) |
| USC | Universitäts Sport Club (German: University Sports Club) |
| USC | Utrechtsch Studenten Corps (NL) |
| USC | United States Champion |
| USC | Uterine Serous Carcinoma |
| USC | Universal Service Card |
| USC | User Service Center |
| USC | Unión Social Cristiana (Spanish: Social Christian Union, El Salvador) |
| USC | United Sugar Company |
| USC | US Can Corporation (stock symbol) |
| USC | Ultra Sonic Cleaning |
| USC | Up Stage Center |
| USC | Using Service Code |
| USC | Urban Street Canyon |
| USC | Universal Service Code |
| USC | Unified Speech Codec |
| USC | Ultra Software Corporation |
| USC | Unione Sanguis Christi (Sanguis Christi Union) |
| USC | Ultimate Stag Challenge |
| USC | Unit Shipping Container |
| USC | Urban Services Committee |
| USC | USAREUR Subordinate Command |
| USC | US Cryogenics (Nashville, Tennessee) |
| USC | United States Cavers (forum) |
| USC | United Styles Crew (gaming group) |
| USC | Unequally Shared Channel (channel reservation scheme) |
| USC | Underground Service Cable (power distribution) |
| USC | Uniformly Stable Conformal |