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PAI-1 mRNA expression was dramatically elevated in UUO kidneys, and PF (50, 100 mg/kg) administration significantly inhibited PAI-1 expression.
PF inhibited epithelial--mesenchymal transition in kidneys of mice induced by UUO Of
Marked increase in the [alpha]-SMA-positive area in Model group after UUO.
Furthermore, we investigated the effect of PF on mRNA expression of Snaill during UUO.
PF recovered the ratio of TGF-[beta]1 and BMP-7 in kidneys of mice induced by UUO
The effects of PF and losartan on TGF-[beta] and BMP-7 mRNA expressions were assessed at day 7 after UUO operation.
The mRNA ratio 0f TGF-[beta]1/BMP-7 in UUO kidneys elevated about 8-fold as compared to Sham.
PF inhibited phosphorylation of Smad 2/3 in kidneys of mice induced by UUO
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