VapBVirulence Associated Protein B (pathogenicity)
VAPBVirginia Associated Press Broadcasters
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Muotri said the finding suggests reduced VAPB protein levels may be a key to the development of ALS8 and perhaps other forms of the disease as well, including sporadic or non-hereditary ALS, where reduced VAPB protein levels have also been documented.
The VAPB protein is involved in many cellular processes, so it seems likely it contributes to the pathogenesis of other forms of ALS," Muotri said.
Citation: "Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem-cells of ALS8 patients;" Miguel Mitne-Neto, et al.