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VCAM-1 |
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Early E-selectin, VCAM-1, ICAM-1, and late major histocompatibility complex antigen induction on human endothelial cells by flavivirus and comodulation of adhesion molecule expression by immune cytokines. Endovasc's pending Phase III products include ANGIOGENIX(TM), a potent small molecule that uniquely uses the acetylcholine receptor agonist (nAChR) pathway shown to stimulate DNA synthesis and upregulate growth factors such as vascular endothelial growth factor (VEGF) transforming growth factor (TGF)-1 basic fibroblast growth factor (bFGF) and various essential adhesion molecules such as VCAM-1 necessary for angiogenesis. Human pulmonary responses to DEPs include increased neutrophils and B-lymphocytes in lavage fluids, increased expression of endothelial adhesion molecules ICAM-1 (intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) in bronchial biopsies, and increased neutrophils and platelets in peripheral blood (Salvi et al. |
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