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VEGFR-3

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AcronymDefinition
VEGFR-3vascular endothelial growth factor C/D receptor


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Multikinase inhibitors - Sorafenib (Nexavar[R], Bayer Pharmaceuticals): inhibits FLT-3, KIT, VEGFR-2, VEGFR-3, PDGFR-[beta] - Sunitinib (Sutent[R], Pfizer Inc.
The key, indicate the researchers, is the unexpected presence of large amounts of the protein VEGFR-3 (vascular endothelial growth factor receptor-3) on the top epithelial layer of normal healthy corneas.
Nexavar (sorafenib) was shown to inhibit multiple intracellular (C-RAF, B-RAF and mutant B-RAF) and cell surface kinases (KIT, FLT-3, RET, VEGFR-1, VEGFR-2, VEGFR-3, and PDGFR-U).
 
 
 
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