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One possibility is that arsenic may alter the normal vasomotor tone of blood vessels, which rises from contractility of vascular smooth muscle cells. Angiotensin II causes endothelial cell and vascular smooth muscle cell migration, growth, and proliferation; (39,61) it also stimulates cardiac fibroblast growth and hypertrophy. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. |
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