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Similar effects were also observed in aortic rings without endothelium, suggesting that vascular smooth muscle plays a key role in enhancing vasoconstriction induced by arsenite. [10] Studies using direct nerve stimulation in experimental animals have demonstrated that vascular smooth muscle is more responsive to irregular bursts of stimulation ranging from 2 to 5 bps than to continuous stimulation with the same average stimulation frequency. AP23573 also blocks the proliferation and migration of vascular smooth muscle cells, the primary cause of narrowing and reblockage of injured arteries, and is an analog of sirolimus, another mTOR inhibitor that has been approved for use in drug-eluting stents. |
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