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Vitronectin adsorption to chrysotile asbestos increases fiber phagocytosis and toxicity for mesothelial cells. But if Lessey and his research team prove correct about the role of a protein known informally as beta-3 -- the beta-3 subunit of the vitronectin receptor integrin -- they may have taken one step closer to understanding the puzzling nature of endometriosis and its association with infertility. The study showed that the linear tumstatin peptides inhibit the endothelial cells in the presence of vitronectin, fibronectin and collagen I, indicating they have excellent potential to reduce angiogenesis," said Dr. |
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