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As part of Icagen's broad pain program, we have worked with our colleagues at Abbott to identify compounds which selectively inhibit one subtype of voltage-gated sodium channel, Nav1. Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Hyperkinetic twitching and spinal curvature are commonly observed symptoms resulting from exposure to a voltage-gated sodium channel activator such as brevetoxin or ciguatoxin in medaka embryos (Edmunds et al. |
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