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WT1 |
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Notably, approximately 20% of these candidate genes have already been implicated in Mendelian diseases, including disease genes for rare forms of cancer susceptibility, such as the breast cancer susceptibility loci BRCA1 and BRCA2, neurofibromin 1 (NF1), retinoblastoma locus RB1, Wilms tumor locus WT1, and ataxia telangiectasia mutated (ATM). At constant rotor speed the influence of WT1 and WT2 on batch temperature early in the mixing cycle determines the stresses which can be generated. INNO-305 is a unique WT1 peptide immunotherapy being developed for acute myelogenous leukemia (AML). |
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