| Acronym | Definition |
|---|
| WISE | Web Information Systems Engineering |
| WISE | Women in Science and Engineering |
| WISE | World Information Service on Energy |
| WISE | World Institute of Scientology Enterprises |
| WISE | Women's Ischemia Syndrome Evaluation (Epidemiology Data Center; University of Pittsburgh) |
| WISE | Wilberforce Institute for the study of Slavery and Emancipation (UK) |
| WISE | Winter Semester |
| WISE | Women Into Science and Engineering |
| WISE | Wide-Field Infrared Survey Explorer |
| WISE | Washington Internships for Students of Engineering |
| WISE | World and Islam Studies Enterprise |
| WISE | Web-based Integrated Science Environment |
| WISE | Workshop on Information Systems and Economics |
| WISE | Windows Interface Source Environment (Microsoft) |
| WISE | Workers in the Sex Industry (CBO, Act, Australia) |
| WISE | Wireless System Engineering |
| WISE | Wing In Surface Effect |
| WISE | Wireless Signal Extraction (transportation; real-time traffic information) |
| WISE | Workshop on Inspection in Software Engineering |
| WISE | World Infrastructure Security Environment |
| WISE | Women In Search of Equity |
| WISE | Web Intelligence Search Engine (US DoD) |
| WISE | Women in Spinal Cord Evolution (Frederick, MD) |
| WISE | Web Integrated Systems Engineering |
| WISE | World Institute for Social Enlightenment (California) |
| WISE | World Information Systems Exchange |
| WISE | Walk-In Synthetic Environment |
| WISE | Western Investigation & Security Enterprises, Inc. |
| WISE | Windows of Information for Student Education (North Carolina) |
| WiSE | Workstation Interface Software Engineering (CDI) |
| WISE | Wholesale Interservice Support Agreement |
| WISE | Workplace Information Systems Enhancement |
| WISE | Work Initiatives Leading to Sustainable Employment (UK) |
| WISE | Write Improved SOWs Easily (manual) |