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Thus, for example, a polymorphism in an XME that decreases the catalytic efficiency of an enzyme that detoxifies a particular drug might make the standard dose of that drug toxic.
Functional polymorphisms in XMEs include a) point mutations in coding regions of genes resulting in amino acid substitutions, which may alter catalytic activity, enzyme stability, and/or substrate specificity; b) duplicated or multiduplicated genes, resulting in higher enzyme levels; c) completely or partially deleted genes, resulting in no gene product; and d) splice site variants that result in truncated or alternatively spliced protein products (Ingelman-Sundberg et al.
Functional polymorphisms in XMEs can affect the balance of metabolic intermediates produced during biotransformation, and some of these intermediates can bind and induce structural changes in DNA or binding other critical macromolecules, such as sulfhydryl-containing proteins.
One can contrast the role of polymorphisms in XMEs and other components of the environmental response system with variants that are highly penetrant (i.
With the in-depth understanding of and relationships with key players in both China and Hollywood, XME has a unique ability to competitively identify, develop, structure and execute China-U.
co-production to be shot in 3D and having the opportunity to work with XME on this very unique and gripping thriller," said Steve Squillante.