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XPD |
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39, respectively); XPD 312Asn and XPD 751Gln were associated with significant increases in chromatid breaks compared with wild types (16. The scientists looked for variations in two genes, dubbed XPD and XRCC1, that encode proteins governing DNA repair. 1] Antigen recognition Lys69Glu protein XPD (ERCC2) Nucleotide excision Lys751Gln repair (NER) enzyme system XPF NER multiple SNPs XRCC1 Base excision repair Arg399Gln APE1 Apurinic/apyrimidinic Asp148Glu endonuclease 1 ALAD [delta]-Aminolevulinic G177C acid dehydratase TLR4 Type I transmembrane A896G protein D299G TNF-[alpha] Cytokine G-308A 1999 Gene Effect of polymorphism References CYP1A1 Unknown Spurr et al. |
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