XRPD

AcronymDefinition
XRPDX-Ray Powder Diffraction
References in periodicals archive ?
A comprehensive investigation of solid aerosols using XRPD and AAS Techniques.
Radioactive pollution and its Health Hazards, A study by SSNTDs and XRPD Analysis M.
The technique, which involves the use of XRPD, analyzes tablets without requiring their removal from their blister packaging.
XRPD is already well established as a key analytical technique in the pharmaceutical industry, used for the discovery, development and manufacture of drugs.
XRPD Measurements of Tablets Through the Blister Figure 2 shows XRPD data from a single commercial tablet, both with and without the surrounding blister.
Technological methods of addressing the issue must also be part of the solution, and this article demonstrates a novel XRPD method that can now be used for monitoring drug quality.
This dissolution and XRPD behavior was not observed for the same tablet formulation stored in a more conservative packaging configuration (inside PE flasks with moisture absorbers).
In addition to complete pharmaceutical formulation development project planning and execution, Integral BioSystems offers individual, rapid testing that includes NMR, UV-Vis, FUR, microscopy, DSC-TGA, particle sizing, Log P, pH, SEM, XRPD, osmolality, Karl Fisher, volatiles by GC, and dose verification and viscometry.
In addition to complete pharmaceutical formulation development project planning and execution, Integral BioSystems offers individual, rapid testing that includes NMR, UV-Vis, FTIR, microscopy, DSC-TGA, particle sizing, Log P, pH, SEM, XRPD, osmolality, Karl Fisher, volatiles by GC, and dose verification and viscometry.
XRPD can also be used to identify crystalline materials, pursuant to USP <941> testing, as well as quantitative phase analysis and assessment of the degree of crystallinity of solids.
Installed and fully operational, the XRPD instrument is equipped with a very sensitive LYNXEYE detector, which allows methods to be developed and optimized quickly without compromising data quality, according to the company.
Preformulation--API Characterization, polymorph identification, salt screen/selection, thermal evaluation (DSC, TGA and/or hot stage), pKa determination (calculated & experimental), Log P/ Log D determination, pH solubility profiles, XRPD, particle size, moisture content, water activity, solid state characterization.