For those who missed it, a prominent retrovirologist, Judy Mikovits, published a very informative article on XMRV
in the October 2009 issue of Science.
They examined blood samples from 147 people diagnosed with chronic fatigue syndrome and 146 healthy subjects and found no evidence of either XMRV
or pMLV infection in either group.
In 2009, Science reported that two thirds of blood taken from individuals with the syndrome tested positive for the mouse leukemia virus XMRV
, compared with the meager 3.
In another study, Vinay Pathak at the National Cancer Institute in Frederick, Maryland, suggests that XMRV
originated in lab mice between 1993 and 1996 - after many of the people in Lombardi's study were diagnosed with CFS - and so cannot be the cause.
But they found no evidence of XMRV
or any other mouse-related virus.
Therefore, we studied the presence of XMRV
and polytropic MLV-related retroviruses in a group of patients with fibromyalgia.
We are also excited about CMX157's in vitro antiviral activity against XMRV
, a retrovirus recently associated with chronic fatigue syndrome.
Their results linked a family of human gamma retroviruses (to which XMRV
belongs) to ME/CFS at a rate of 86.
Michael Busch, director of the Blood Systems Research Institute in San Francisco and a member of a federally funded group studying whether the retrovirus XMRV
, which some studies show linked to chronic fatigue syndrome, poses a threat to the blood supply told The Wall Street Journal, "We learned from HIV that we have to react aggressively to every next potential threat.
Partial list of viruses and the year they were reported to be associated with MS (adapted from R Johnson, 1998) (33) Virus Years Rabies 1946, 1964 Herpes simplex 1964 Scrapie agent 1965 MS-associated agent 1962 Parainfluenza virus 1 1972 Measles 1972 Simian virus 5 1978 Chimpanzee cytomegalovirus 1979 Coronavirus 1980 SIMON-like virus 1982 Tick borne encephalitus flavivirus 1982 HTLV-1 1986 LM7 (retrovirus)--MSRV 1989, 1997 HSV-1 1989 MS1533 (retrovirus) 1994 HHV-6 1993, 1995 Borna virus 1998 EBV 1998, 2003, 2007 Varicella zoster 2004 XMRV
is a retrovirus like HIV, which inserts a copy of its DNA into the chromosomes of the cells it infects, disrupting normal cell development.
A recent US study found two-thirds of ME patients had a virus called XMRV