These included the International Nifedipine GITS Study of Intervention as a Goal in Hypertension Treatment (INSIGHT), (23) the Nordic Diltiazem (NORDIL) study, (24) the Australian National Blood Pressure Study 2 (
ANBP2), (28) the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial, (26) the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial, (29) and the Irbesartan in Heart Failure with Preserved Systolic Function (I-PRESERVE) study.
Tambien apunta que, si bien los diureticos tipo tiazidas fueron recomendados por el JNC 7 para iniciar el tratamiento en la mayoria de los pacientes con HTA, datos posteriores procedentes de los estudios LIFE (Losartan Intervention For Endpoint Reduction in Hypertension Study), ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial),
ANBP2 (Second Australian National Blood Pressure Study) y ACCOMPLISH (Avoiding Cardiovascular Events Through Combination Therapy In Patients Living With Systolic Hypertension), indican la necesidad de un enfoque mas flexible.