Impact of
calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia.
Calreticulin is the dominant prophagocytic signal on multiple human cancers and is counterbalanced by CD47.
It has been established that in some patients with MPNs, mutation of
calreticulin (CALR) occurs.
(EA Pharma) have revealed a mechanism in which an analogue (ER-464195-01) of Eisai's in-house discovered E6007 inhibits integrin activation by dissociating interaction between
calreticulin (CRT) and integrin alpha 4 (ITGA4), suppressing adhesion and infiltration of leukocytes overall.
Calreticulin (CALR) is a major regulator of [Ca.sup.2+] levels in the endoplasmic reticulum (ER) and shows elevated expression in the SCN according to RNA in situ hybridization results.
Macrophages eat cancer cells using their own
calreticulin as a guide: roles of TLR and Btk.
Lower panel, colocalization of Nesprin2 detected by mAb K81-116-6 with ER marker
calreticulin in HaCaT cells.
Zhao et al., "Hepatitis B virus-induced
calreticulin protein is involved in IFN resistance," The Journal of Immunology, vol.
Her initial evaluation was negative for BCR-ABL PCR testing, Janus kinase-2,
calreticulin, and MPL mutations.