| Acronym | Definition |
|---|
| COTS | Commercial Off-The-Shelf (products) |
| COTS | Commercial off-the-Shelf |
| COTS | Commercial Orbital Transportation Services (NASA commercial program to develop a vehicle that can reach low earth orbit) |
| COTS | Commercial Off the Shelf |
| COTS | Crown-of-Thorns (starfish) |
| COTS | Coalition on Temporary Shelter (Detroit, Michigan) |
| COTS | Committee On Temporary Shelter |
| COTS | Common-Off-The-Shelf |
| COTS | Childlessness Overcome Through Surrogacy |
| COTS | Cargo Offload and Transfer System (US DoD) |
| COTS | Consideration of Others Training Seminar |
| COTS | Children of the Sun (song) |
| COTS | Component Off the Shelf (software development) |
| COTS | Cheap Off the Shelf |
| COTS | Crest of the Stars (anime) |
| COTS | Council on Technology Services |
| COTS | Clean, Oil, Test and Stencil (railway brake systems) |
| COTS | Chronicles of the Sword (gaming) |
| COTS | Chapter Operations Training Seminar |
| COTS | Chapter Officer Training School (SPEBSQSA) |
| COTS | Convention of the States (US Constitution) |
| COTS | Church on the Street (religious program) |
| COTS | Corrected on the Spot |
| COTS | Cleaned, Oiled, Tested and Stenciled (railroad air brakes) |
| COTS | Center Outlook Tactical and Strategic |
| COTS | Committee On Technical Security |
| COTS | Center Operations and Technical Support |
| COTS | Container Offloading & Transfer System |