| Acronym | Definition |
|---|
| CISC | Complex Instruction Set Computer |
| CISC | Canadian Institute of Steel Construction |
| CISC | Cisco Certification |
| CISC | Circuit Switch |
| CISC | Criminal Intelligence Service Canada |
| CISC | Clean Intermittent Self-Catheterization (urology) |
| CISC | Commonwealth Information Security Center (Virginia) |
| CISC | CRTC Interconnection Steering Committee (Canadian Radio-television and Telecommunications Commission) |
| CISC | Center for Forskning I Idræt, Sundhed og Civilsamfund (Denmark) |
| CISC | City University of New York Institute for Sustainable Cities (New York, NY) |
| CISC | Central Instructional Support Center |
| CISC | Criminal Investigation Service Command |
| CISC | Construction Industry Stabilization Committee (now defunct) |
| CISC | Congress of the International Society of Citriculture |
| CISC | Configuration Interaction with Size-Consistency |
| CISC | Creative Integrated Solutions Consortium |
| CISC | Clare Immigrant Support Centre (Ireland) |
| CISC | Computer & Information Sciences Course (academia) |