[8.] Rayner BL, Owen PE, King JA, et al A new mutation, R563Q, of the beta subunit of the
epithelial sodium channel associated with low-renin, low-aldosterone hypertension.
Lipoxin A(4) activates alveolar
epithelial sodium channel, Na, K-ATPase, and increases alveolar fluid clearance.
Menon, "
Epithelial sodium channels and hypertension," Drug Metabolism and Disposition, vol.
The company will lead development of P-321, an investigational
epithelial sodium channel inhibitor for the potential treatment of dry eye disease in adults, with the opportunity for Parion to co-fund.
Hanukoglu et al., "Mutations in subunits of the
epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1," Nature Genetics, vol.
Isseroff, "The
epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes," Journal of Cell Science, vol.
The R563Q mutation of the
epithelial sodium channel beta-subunit is associated with hypertension.
(7) Further molecular biology and biochemistry research identified sgk as an AIP that increases
epithelial sodium channel (ENaC) activity.
Beta and subunits of the
epithelial sodium channel (ENaC) compared with normotensive controls 2 AY ENaC and ENaC gene variants were significantly more prevalent in the patients with resistant hypertension14.
The alteration of
epithelial sodium channel (ENac) and NaK-2Cl (NKCC) co-transporter expression in lungs of hamsters infected with Leptospira was reported.