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epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity," Critical Reviews in Toxicology, vol.
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Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases," American Journal of Physiology-Renal Physiology, vol.
Abbreviations SPMs: Specialized proresolving lipid mediators DHA: Docosahexaenoic acid PMNs: Polymorphonuclear leukocytes Ri: Resolution interval EPA: Eicosapntemacnioc acid MCTR: Maresin conjugate in tissue regeneration sEH: Soluble
epoxide hydrolase 12-LOX: 12-Lipoxygenase LTC4S: Leukotriene C4 synthase GSTM4: Glutathione S-transferase MU 4 GGT: Gamma-glutamyltransferase DPEP: Dipeptidase NF-[kappa]B : Nuclear factor kappa B PDGF: Platelet-derived growth factor TGF-[beta]1: Transforming growth factor [beta]1 TRPV1: Transient receptor potential V1.
Lin et al., "Soluble
epoxide hydrolase deficiency or inhibition attenuates MPTP-induced parkinsonism," Molecular Neurobiology, vol.
The report provides comprehensive information on the Soluble
Epoxide Hydrolase (Epoxide Hydratase or Aryl Epoxide Hydrase or EC 3.3.2.10), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Soluble
epoxide hydrolase (sEH), a member of the
epoxide hydrolase family, is found mostly in cytosol but also in the peroxisomes of some mammalian tissues including liver, kidney, intestine and vascular tissues (Morisseau and Hammock 2013).
It aimed to determine the impact of a group of chemicals called "nitro fatty acids" on the activity of an enzyme called soluble
epoxide hydrolase and the knock on effects on blood pressure.
Thus, the study concludes that the protective effect of the Mediterranean diet, combining unsaturated fats and vegetables abundant in nitrite and nitrate, comes at least in part from the nitro fatty acids generated which inhibit soluble
Epoxide Hydrolase to lower blood pressure.
Arene oxides derived from aromatic anticonvulsants bind to cell constituents if they are not rapidly detoxified by
epoxide hydrolase. These metabolites act as haptens and render the keratinocytes antigenic by binding to them.
Epoxide hydrolase is the enzyme involved in VPA metabolism, the inhibition of which results in accumulation of epoxides.