| Acronym | Definition |
|---|
| GC | General Contractor |
| GC | Grand Chase (video game) |
| GC | Government of Canada |
| GC | Golf Course |
| GC | Guitar Center (musical equipment chain store) |
| GC | Games Convention (Leipzig, Germany) |
| GC | Gran Canaria (Canary Islands, Spain) |
| GC | Garbage Collection (LISP) |
| GC | GameCube (Nintendo) |
| GC | Good Condition |
| GC | Gold Coast (Queensland, Australia) |
| GC | Gas Chromatography |
| GC | General Conference (United Methodist Church) |
| GC | General Counsel |
| GC | Glucocorticoid |
| GC | Ground Control |
| GC | Google Chrome (web browser) |
| GC | Global Change |
| GC | Green Card |
| GC | Gift Certificate |
| GC | Grammar and Composition |
| GC | General Chat (website) |
| GC | General Convention (Episcopal Church) |
| GC | Golf Channel |
| GC | Grand Champion (various organizations) |
| GC | Grand Champion |
| GC | Global Community (Left Behind book series) |
| GC | Geocities |
| GC | Gold Certificate (currency) |
| GC | Government College (Lahore, Pakistan) |
| GC | Génie Civil (French: Civil Engineering) |
| GC | Gas Chromatograph |
| GC | Global Compact (UN) |
| GC | Great Circle |
| GC | Gamecube Controller (gaming equipment) |
| GC | Guardia Civil (Spain) |
| GC | German Democratic Republic |
| GC | Good Charlotte (band) |
| GC | Government Code |
| GC | Good Conduct (Medal USMC) |
| GC | George Carlin (comedian) |
| GC | General Classification (cycling) |
| GC | Greencastle (Indiana) |
| GC | Golden Child (musician) |
| GC | George Cross |
| GC | Global Crossing |
| GC | Global Catalog |
| GC | Geocoin (geocaching) |
| GC | Greek Cypriot |
| GC | Good Call |
| GC | Grand Coulee (Washington) |
| GC | Genome Canada |
| GC | Good Counsel |
| GC | Global Consulting |
| GC | Greater Cincinnati |
| GC | Goshen College (Indiana) |
| GC | Group Captain (Royal Air Force) |
| GC | Game Card (gaming) |
| GC | Golden Coin (gaming) |
| GC | Ghirardelli Chocolate |
| GC | Government Contribution |
| GC | Going Commando (game) |
| GC | Gliomatosis Cerebri (rare primary brain tumor) |
| GC | Granular Computing |
| GC | Guidance Control |
| GC | Government Contractor |
| GC | Gonococcus |
| GC | German Club |
| GC | Grand Circle |
| GC | Geographic Center |
| GC | Graduate Council (various schools) |
| GC | Ghetto Child |
| GC | Global Configuration |
| GC | Georgian College (Barrie, Ontario, Canada) |
| GC | Global Constraint |
| GC | Gravity Center (physics) |
| GC | Grade Change |
| GC | Greensboro College (North Carolina) |
| GC | Goldsmiths College (UK) |
| GC | Grammar Check |
| GC | Garbage Can |
| GC | Grand Charm (gaming) |
| GC | Groove Coverage (band) |
| GC | Graphics Context |
| GC | Guidance Counselor |
| GC | Gigacycle (now Gigahertz) |
| GC | Gas Chamber |
| GC | Greenville College (Greenville, Illinois) |
| GC | Guanine-Cytosine (DNA base pairing) |
| GC | Generic Code |
| GC | Government Centre |
| GC | Galactic Conquest (computer game) |
| GC | Group-Specific Component (proteins) |
| GC | Group Control |
| GC | Gun Captain (US Navy) |
| GC | Group Command (ITU-T Rec. T.30) |
| GC | Gonorrhea Culture |
| GC | Goldbach's Conjecture |
| GC | Global Custodians |
| GC | Garrison Commander |
| GC | Galvanic Corrosion |
| GC | General Casualty (insurance company) |
| GC | Global Calling |
| GC | General Cost |
| GC | General Cable Corporation |
| GC | Germinal Centre (lymph nodes) |
| GC | Gyrocompass |
| GC | Greeley Central High School (Greeley, Colorado) |
| GC | Gas Cooled |
| GC | Government Connect |
| GC | Gem City |
| GC | Guard Channel |
| GC | Guidance Computer |
| GC | General Discharge |
| GC | Greek Circle (magazine; Chicago, IL) |
| GC | General Corrosion (protection) |
| GC | Gamecenter.com (C|Net) |
| GC | Gemcitabine/Carboplatin |
| GC | Gambia International Airlines (IATA airline code) |
| GC | Governos Constitucionais (Portuguese: Constitutional Governments) |
| GC | Ghost Click |
| GC | Guardians Council (Iranian government agency) |
| GC | Garden Center, Inc |
| GC | Global Conferencing (Global One) |
| GC | Guarded Command |
| GC | Clayey Gravels (soil type) |
| GC | Game Chick |
| GC | Game Càfe |
| GC | Gravimetric Calibrator (semiconductors) |
| GC | Globus Consortium |
| GC | Group Currency (finance) |
| GC | Gaining Command |
| GC | Geneva Convention Relative to the Protection of Civilian Persons in Time of War, 12 August 1949 |
| GC | Glivenko-Cantelli (condition) |
| GC | Galactic Commander (gaming) |
| GC | Gyro Control |
| GC | Gavel Club |
| GC | Generalized Compound (model) |
| GC | Gamecatcher (magazine) |
| GC | Graphics Conferencing |
| GC | Grand Computers |
| GC | General Communications Incorporated |
| GC | General Chairside Examination |
| GC | GregChant Enterprises, LTD |
| GC | Garrison Code (US Army) |
| GC | Grand Chinchilla (rabbit breed) |
| GC | Guaranty Period Complete |
| GC | Ground Cadets |
| GC | Giwirr Consultants |